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Metadata
ID DOID:0081065
Name EZB diffuse large B-cell lymphoma
Definition A diffuse large B-cell lymphoma that is categorized as EZB with high probability by the LymphGen algorithm. This is based on a combination of genetic features and EZB DLBCLs often, but do not always, have hot spot mutations in EZH2 and/or a BCL2 translocation. This class can be further subdivided into two sub-classes EZB-MYC+ and EZB-MYC- using the double hit gene expression signature (DHITsig). This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting IRF8, which can be coding or non-coding.
https://pubmed.ncbi.nlm.nih.gov/29641966/, https://www.ncbi.nlm.nih.gov/articles/PMC8459709/
Xrefs

NCI:C148398

Subsets

DO_cancer_slim

NCIthesaurus

Synonyms

EZB DLBCL [EXACT]

Parent Relationships

is_a diffuse large B-cell lymphoma

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