| Metadata | |
|---|---|
| ID | DOID:0081065 |
| Name | EZB diffuse large B-cell lymphoma |
| Definition | A diffuse large B-cell lymphoma that is categorized as EZB with high probability by the LymphGen algorithm. This is based on a combination of genetic features and EZB DLBCLs often, but do not always, have hot spot mutations in EZH2 and/or a BCL2 translocation. This class can be further subdivided into two sub-classes EZB-MYC+ and EZB-MYC- using the double hit gene expression signature (DHITsig). This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting IRF8, which can be coding or non-coding. https://pubmed.ncbi.nlm.nih.gov/29641966/, https://www.ncbi.nlm.nih.gov/articles/PMC8459709/ |
| Xrefs | |
| Subsets |
DO_cancer_slim NCIthesaurus |
| Synonyms |
EZB DLBCL [EXACT] |
| Parent Relationships |