| Metadata | |
|---|---|
| ID | DOID:643 |
| Name | progressive multifocal leukoencephalopathy |
| Definition | A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma. http://www.merck.com/mmpe/sec16/ch217/ch217f.html, http://www.merriam-webster.com/medical/progressive%20multifocal%20leukoencephalopathy, http://www.ninds.nih.gov/disorders/pml/pml.htm |
| Xrefs |
SNOMEDCT_US_2023_03_01:22255007 |
| Subsets |
DO_infectious_disease_slim DO_rare_slim NCIthesaurus |
| Synonyms |
PML [RELATED] |
| Parent Relationships | |
| Subclass Logical Relationships |
has material basis in some JC polyomavirus has symptom some dysarthria has symptom some hemiparesis has symptom some aphasia has phenotype some Cognitive impairment has symptom some coma |