Metadata | |
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ID | DOID:643 |
Name | progressive multifocal leukoencephalopathy |
Definition | A viral infectious disease that involves reactivation of JC polyomavirus (Betapolyomavirus secuhominis) in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma. https://www.ninds.nih.gov/health-information/disorders/progressive-multifocal-leukoencephalopathy, http://www.merck.com/mmpe/sec16/ch217/ch217f.html, http://www.merriam-webster.com/medical/progressive%20multifocal%20leukoencephalopathy |
Xrefs |
SNOMEDCT_US_2023_03_01:22255007 |
Subsets |
DO_infectious_disease_slim DO_rare_slim NCIthesaurus |
Synonyms |
PML [RELATED] |
Parent Relationships | |
Subclass Logical Relationships |
has symptom some dysarthria has material basis in some Betapolyomavirus secuhominis has symptom some aphasia has symptom some hemiparesis has phenotype some Cognitive impairment has symptom some coma |